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Late-appearing MLL rearrangement arising as a secondary change in adult acute myeloid leukemia

Lookup NU author(s): Dr Anne Lennard, Dr Nicholas Bown

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Abstract

Rearrangements of MLL are regarded as primary oncogenic events in acute leukemia. We report the case of a patient with acute myeloid leukemia with a complex abnormal karyotype at diagnosis who showed a putative stem line with monosomy 5 and a rearrangement of chromosome 17 as the only abnormalities and an evolved clone with an additional t(7,16,11)(p1?4; p13;q23) after treatment. Fluorescence in situ hybridization analysis confirmed that the translocation had resulted in an MLL rearrangement not present in the stem line or in the complex clones found at diagnosis. To date, this is the first report of an MLL rearrangement evolving as a secondary abnormality within a preexisting leukemic clone. © 2002 Wiley-Liss, Inc.

Publication metadata

Author(s): Rowe, D., Breese, G., Lennard, A.L., Bown, N.P.

Publication type: Article

Publication status: Published

Journal: Genes Chromosomes and Cancer

Year: 2002

Volume: 34

Issue: 1

Pages: 126-128

Print publication date: 01/01/2002

ISSN (print): 1045-2257

ISSN (electronic): 1098-2264

URL: http://dx.doi.org/10.1002/gcc.10011

DOI: 10.1002/gcc.10011

PubMed id: 11921290

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