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Flow-mediated nitric oxide activity in the forearm vasculature of premenopausal women

Lookup NU author(s): Professor Steve Robson, Professor Gary Ford

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Abstract

Aims: Nitric oxide (NO) is involved in acute flow-mediated vasodilatation in various vascular beds. We determined whether acutely increasing flow in the human forearm of premenopausal women increases vascular NO activity. Methods: Forearm blood flow (FBF) was measured by venous occlusion plethysmography. Responses to brachial artery infusion of noradrenaline (a control vasoconstrictor, 20, 50, and 100 ng min-l, each for 5 min) and NG-monomethyl L-arginine (L-NMMA), an NO synthase inhibitor (200, 400, and 800 μg min-1, each for 5 min), were determined in eight premenopausal women before and following elevation of basal FBF with glyceryl trinitrate (GTN) on two separate occasions. Results: Flow elevation with GTN increased responses to L-NMMA (summary measure 103±12 vs 65±12 arbitrary units, P<0.05), but not to noradrenaline (95±35 vs 74±12, P=0.50). Conclusions: Acute elevation of FBF in nonpregnant women is associated with enhanced responses to NO synthase inhibition, consistent with flow-mediated increased NO activity.


Publication metadata

Author(s): Anumba DOC, Robson SC, Ford GA

Publication type: Article

Publication status: Published

Journal: British Journal of Clinical Pharmacology

Year: 2002

Volume: 53

Issue: 3

Pages: 332-336

Print publication date: 01/01/2002

ISSN (print): 0306-5251

ISSN (electronic): 1365-2125

Publisher: Wiley-Blackwell Publishing

URL: http://dx.doi.org/10.1046/j.0306-5251.2001.01559.x

DOI: 10.1046/j.0306-5251.2001.01559.x

PubMed id: 11874398


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