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A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies

Lookup NU author(s): Dr Clive Ballard, Dr Margaret Piggott, Emeritus Professor Robert Perry, Professor John O'Brien, Dr Elise Rowan, Emeritus Professor Elaine Perry


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Background: Depression is a common and distressing problem in the context of dementia, and is significantly more common in Dementia with Lewy bodies (DLB) than in Alzheimer's disease. The neurochemical basis for depression in DLB has not been investigated. Aim: To investigate the association between depression and 5HT transporter re-uptake binding in DLB patients. Method: A representative cohort of dementia patients received annual assessments, which included a standardised evaluation of depression until death. At post-mortem, (3H) cyanoimipramine autoradiography was used to quantify 5HT transporter re-uptake sites in the hippocampus and adjacent temporal cortex (Brodmann Area-BA 36, and 20); and parietal neocortex (BA 7a). Results: Twenty-one cases were evaluated neurochemically, of whom seven had experienced a major depressive disorder. Major depression was associated with a significant preservation of 5HT transporter re-uptake sites in the parietal neocortex compared with non-affected cases (BA 7a area 1 t=3.3, P=0.004; BA 7a area 3 t=3.8, P=0.001). Conclusion: This preliminary report is important in challenging some of the assumptions about cortical monoamine functioning in depressed dementia. © 2002 Elsevier Science B.V. All rights reserved.

Publication metadata

Author(s): Ballard C, Johnson M, Piggott M, Perry R, O'Brien J, Rowan E, Perry E, Lantos P, Cairns N, Holmes C

Publication type: Article

Publication status: Published

Journal: Journal of Affective Disorders

Year: 2002

Volume: 69

Issue: 1-3

Pages: 219-223

Print publication date: 01/01/2002

ISSN (print): 0165-0327

ISSN (electronic): 1573-2517

Publisher: Elsevier


DOI: 10.1016/S0165-0327(00)00375-X

PubMed id: 12103469


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