ePrints

Field change and oral cancer: New evidence for widespread carcinogenesis?

Lookup NU author(s): Professor Peter Thomson

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Patients with oral squamous cell carcinoma (OSCC) are at risk of developing second or multiple primary cancers as a result of field cancerization in the upper aerodigestive tract. In order to quantify the incidence of field change observable in oral mucosa, 26 consecutive new (untreated) patients presenting with a unilateral OSCC (18) or a premalignant lesion (eight) underwent 'mirror image' biopsies from clinically normal-looking mucosa at corresponding anatomical sites. A total of 15 patients (58%) demonstrated histologically abnormal tissue upon microscopic examination: six showed reactive change/cellular atypia associated with chronic irritation, seven exhibited frank dysplasia, whilst two displayed carcinoma-in-situ (CIS) or microinvasive SCC. Although not statistically significant, there was an observable trend for the lateral/ventral tongue and floor of mouth to display increased vulnerability to dysplastic change.

Publication metadata

Author(s): Thomson PJ

Publication type: Article

Publication status: Published

Journal: International Journal of Oral and Maxillofacial Surgery

Year: 2002

Volume: 31

Issue: 3

Pages: 262-266

Print publication date: 01/01/2002

ISSN (print): 0901-5027

ISSN (electronic): 1399-0020

Publisher: Churchill Livingstone

URL: http://dx.doi.org/10.1054/ijom.2002.0220

DOI: 10.1054/ijom.2002.0220

PubMed id: 12190131

Altmetrics

Share