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p53 and ageing: Too much of a good thing?

Lookup NU author(s): Emeritus Professor Thomas Kirkwood


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A recent report by Tyner et al. suggests that p53 is bad for longevity. Heterozygotic mice carrying a p53 mutation that apparently enhances the stability of the wild-type protein showed shorter lifespans and faster ageing while also developing fewer tumours. This fits with the idea that cellular ageing is the price paid for better protection against unlimited proliferation of cancer cells. But other work shows that there is a strong positive association between DNA repair-mediated protection against cancer and ageing. So what are we to make of the new data with regard to overall understanding of the mechanisms of ageing? © 2002 Wiley Periodicals, Inc.

Publication metadata

Author(s): Kirkwood TBL

Publication type: Article

Publication status: Published

Journal: BioEssays

Year: 2002

Volume: 24

Issue: 7

Pages: 577-579

ISSN (print): 0265-9247

ISSN (electronic): 1521-1878

Publisher: John Wiley & Sons Ltd.


DOI: 10.1002/bies.10111

PubMed id: 12111716


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