Toggle Main Menu Toggle Search

Open Access padlockePrints

Prostaglandin E2 and treatment outcome in pulp therapy of primary molars with carious exposures

Lookup NU author(s): Professor Paula WaterhouseORCiD, Professor John Whitworth


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Objectives. Prostaglandin E2 (PGE2) has been suggested as an indicator of irreversible pulpitis in permanent teeth [1]. There is scant information on the role of chemical mediators in primary molar pulp inflammation. The aim of this preliminary study was to investigate the levels of PGE2 in blood harvested from root pulp stumps following coronal pulp amputation in vital primary molar teeth with carious exposures. Methods. Seventy-nine cariously exposed primary molars underwent treatment by one of two vital pulp therapy techniques. Blood was harvested from 38 teeth and volume and concentration of PGE2 ([PGE2]) determined [2]. Treatment outcome was assessed from both clinical and radiographic evidence. Results. PGE2 was detected in all samples, with a wide concentration range (1-2641 ng/mL). The distribution was skewed, requiring log transformation. The difference in the mean (log) [PGE2] for radiological success (3.12, SD 1.60) and failure (4.62, SD 1.80) was significant, t = 2.05, P = 0.047. The difference in the mean (log) [PGE2] for clinical success (3.24, SD 1.65) and failure (5.44, SD 1.43) was near-significant, t = 1.84, P = 0.074. Conclusion. [PGE2] correlated positively with radiological outcome following vital pulp therapy.

Publication metadata

Author(s): Waterhouse PJ, Nunn JH, Whitworth JM

Publication type: Article

Publication status: Published

Journal: International Journal of Paediatric Dentistry

Year: 2002

Volume: 12

Issue: 2

Pages: 116-123

Print publication date: 01/03/2002

ISSN (print): 0960-7439

ISSN (electronic): 1365-263X

Publisher: Wiley-Blackwell Publishing


DOI: 10.1046/j.1365-263X.2002.00321.x

PubMed id: 11966889


Altmetrics provided by Altmetric