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A high yielding route to substituted piperidines via the aza-Diels-Alder reaction

Lookup NU author(s): Professor William Clegg

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Abstract

The imine Ph2CHN=CHCO2Et, generated from benzhydrylamine and ethyl glyoxylate, is an excellent dienophile in aza-Diels-Alder reactions, giving diastereomerically pure cycloadducts in high yield. © 2002 Elsevier Science Ltd. All rights reserved.

Publication metadata

Author(s): Bailey PD, Smith PD, Pederson F, Clegg W, Rosair GM, Teat SJ

Publication type: Article

Publication status: Published

Journal: Tetrahedron Letters

Year: 2002

Volume: 43

Issue: 6

Pages: 1067-1070

ISSN (print): 0040-4039

ISSN (electronic): 1873-3581

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/S0040-4039(01)02148-7

DOI: 10.1016/S0040-4039(01)02148-7

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