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Synthesis of a new class of 1,4-bis(diphenylphosphino)-1,3-butadiene bridged diphosphine, NUPHOS, via zirconium-mediated reductive coupling of alkynes and diynes: Applications in palladium-catalyzed cross-coupling reactions

Lookup NU author(s): Dr Simon DohertyORCiD, Dr Edward Robins, Dr Julian Knight, Paul Anthony Champkin, Emeritus Professor Bill CleggORCiD


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The synthesis of a new class of 1,4-bis(diphenylphosphino)-1,3-butadiene was discussed. Catalyst mixtures based on 1,2,3,4-Ph4-NUPHOS were found to be superior to those based on BINAP, with activities of 6900 and 260 (mol of product) (mol of palladium)-1h-1 respectively. The applications in palladium catalyzed cross-coupling reactions were also discussed.

Publication metadata

Author(s): Doherty S, Robins EG, Nieuwenhuyzen M, Knight JG, Champkin PA, Clegg W

Publication type: Article

Publication status: Published

Journal: Organometallics

Year: 2002

Volume: 21

Issue: 7

Pages: 1383-1399

ISSN (print): 0276-7333

ISSN (electronic): 1520-6041

Publisher: American Chemical Society


DOI: 10.1021/om011049w


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