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Genes co-amplified with MYCN in neuroblastoma: Silent passengers or co-determinants of phenotype?

Lookup NU author(s): Dr Debbie Scott, Joanna Elsden, Professor Andrew Pearson, Professor John Lunec

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Abstract

Amplification of the MYCN oncogene in neuroblastoma is associated with poor prognosis. The amplified unit of DNA can be up to 1 Mb in size and so could contain additional genes that affect tumour phenotype. Identification of such genes may assist in optimising the determination of prognosis, and could provide new targets for treatment. Three genes have so far been identified, which are frequently co-amplified with MYCN in neuroblastoma, DDX1, NAG and N-cym. In this review, the known or putative properties of the protein products of the genes are discussed, and their possible roles in determining tumour behaviour are assessed. © 2003 Elsevier Science Ireland Ltd. All rights reserved.


Publication metadata

Author(s): Scott, D., Elsden, J., Pearson, A.D.J., Lunec, J.

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Cancer Letters

Year of Conference: 2003

Pages: 81-86

URL: http://dx.doi.org/10.1016/S0304-3835(03)00086-7

DOI: 10.1016/S0304-3835(03)00086-7

PubMed id: 12880964

Library holdings: Search Newcastle University Library for this item

ISBN: 18727980


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