Browse by author
Lookup NU author(s): Dr Harish Datta, Dr Ben Horrocks
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
One of the most remarkable but neglected aspects of osteoclast function is its unique adaptation that allows the cell to function despite its resorbing surface being exposed to extremely high levels of ambient Ca2+. Recently our studies have provided evidence of continuous transcellular Ca2+ disposal, suggesting that osteoclasts are able to prevent Ca2+ accumulation within the resorptive hemivacuole. It has also been shown that matrix protein degradation products that accumulate within the osteoclast resorptive vacuole are also undergoing transcellular transport by transcytosis. However, both experimental evidence and theoretical considerations suggest that transcellular transport of Ca2+ and matrix protein is likely to occur via distinct routes. In light of these considerations, we are able to provide convincing explanations for the apparent anomalies of osteoclast intracellular [Ca2+] responses to a variety of endocrine stimuli. The understanding of the mechanisms involved in Ca2+ handling by osteoclasts indicates the lack of a simple link between osteoclast function and changes in overall cytosolic [Ca2+].
Author(s): Datta HK, Horrocks BR
Publication type: Article
Publication status: Published
Journal: Journal of Endocrinology
Year: 2003
Volume: 176
Issue: 1
Pages: 1-5
ISSN (print): 0022-0795
ISSN (electronic): 1479-6805
Publisher: BioScientifica Ltd.
URL: http://dx.doi.org/10.1677/joe.0.1760001
DOI: 10.1677/joe.0.1760001
PubMed id: 12525243
Altmetrics provided by Altmetric
