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Lookup NU author(s): Professor David Elliott
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Identification of intratubular germ cell neoplasia (carcinoma in situ, CIS) of the testis is a diagnostic challenge, and markers are sorely needed to assist in accurately identifying the lesion. RNA-binding motif (RBM) protein, encoded by the Y chromosome, is expressed exclusively and consistently in differentiated male germ cells, while it is absent in neoplastic germ cells. Another immunohistochemical marker, placental alkaline phosphatase (PLAP), is commonly used for the detection of undifferentiated germ cells. The current study demonstrates that simultaneous use of the immunohistochemical markers, RBM and PLAP, by double immunolabeling enhances the accuracy of diagnosing CIS, a preinvasive testicular neoplasm.
Author(s): Schreiber L, Lifschitz-Mercer B, Paz G, Yavetz H, Elliott DJ, Kula K, Slowikowska-Hilczer J, Maymon BB-S
Publication type: Article
Publication status: Published
Journal: International Journal of Surgical Pathology
Print publication date: 01/01/2003
ISSN (print): 1066-8969
ISSN (electronic): 1940-2465
Publisher: Sage Publications
PubMed id: 12598912
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