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Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis

Lookup NU author(s): Professor David Elliott


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Identification of intratubular germ cell neoplasia (carcinoma in situ, CIS) of the testis is a diagnostic challenge, and markers are sorely needed to assist in accurately identifying the lesion. RNA-binding motif (RBM) protein, encoded by the Y chromosome, is expressed exclusively and consistently in differentiated male germ cells, while it is absent in neoplastic germ cells. Another immunohistochemical marker, placental alkaline phosphatase (PLAP), is commonly used for the detection of undifferentiated germ cells. The current study demonstrates that simultaneous use of the immunohistochemical markers, RBM and PLAP, by double immunolabeling enhances the accuracy of diagnosing CIS, a preinvasive testicular neoplasm.

Publication metadata

Author(s): Schreiber L, Lifschitz-Mercer B, Paz G, Yavetz H, Elliott DJ, Kula K, Slowikowska-Hilczer J, Maymon BB-S

Publication type: Article

Publication status: Published

Journal: International Journal of Surgical Pathology

Year: 2003

Volume: 11

Issue: 1

Pages: 17-20

Print publication date: 01/01/2003

ISSN (print): 1066-8969

ISSN (electronic): 1940-2465

Publisher: Sage Publications


DOI: 10.1177/106689690301100104

PubMed id: 12598912


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