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An improved method for Lewis acid catalyzed phosphoryl transfer with Ti(t-BuO)4

Lookup NU author(s): Dimitrios Selitsianos, Steven Toms


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Several inorganic esters have been evaluated as phosphoryl transfer catalysts. Of these, Ti(t-BuO)4 was found to be the most effective catalyst giving excellent yields of the desired phosphate esters. The loading of the catalyst could be reduced to a little as 5 mol % for a majority of substrates with no loss in the yield of product. This methodology is significantly more versatile than using TiCl4 and is suitable for the phosphorylation of more complex carbohydrates and molecules of biological interest.

Publication metadata

Author(s): Jones S, Selitsianos D, Thompson KJ, Toms SM

Publication type: Article

Publication status: Published

Journal: Journal of Organic Chemistry

Year: 2003

Volume: 68

Issue: 13

Pages: 5211-5216

ISSN (print): 0022-3263

ISSN (electronic): 1520-6904

Publisher: American Chemical Society


DOI: 10.1021/jo034331g


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