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Lookup NU author(s): Professor Jeffrey Pearson
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The gel nature of mucus is fundamental to its physiological functions; however, the structure of the mucus gel matrix is unclear. Here, small and large deformation rheology has been used to investigate the physical nature of the gel matrix and the forces that maintain this matrix in pig gastric mucus. The gelation process in mucus has been shown to be comparable with that of other polymer gel systems. Nongelling portions of mucin have been identified within the gel network, and the importance of transient, relaxable interactions to the maintenance of the mucus gel matrix has been demonstrated. The structure of the mucus gel matrix is considered in relation to the functional properties of mucus gels.
Author(s): Taylor C, Allen A, Dettmar PW, Pearson JP
Publication type: Article
Publication status: Published
Print publication date: 01/07/2003
ISSN (print): 1525-7797
ISSN (electronic): 1526-4602
Publisher: American Chemical Society
PubMed id: 12857074
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