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Childhood cancer in relation to infections in the community during pregnancy and around the time of birth

Lookup NU author(s): Dr Tibor Nyari, Dr Heather Dickinson, Professor Louise Parker


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In a retrospective cohort study of 404,106 live births in the northern region of England, 1975-1986, we investigated whether higher levels of community infections during the mother's pregnancy and in early life were risk factors for cancer, by diagnostic group (leukaemia and non-Hodgkin's lymphoma, Hodgkin's disease, brain/spinal tumours, neuroblastoma, other tumours), diagnosed 1975-2001 under age 15 years. Logistic regression was used to relate risk to measures of community infections (measles, respiratory and other infections) in 3 prenatal and 2 postnatal quarters. There was an increased risk of Hodgkin's disease among children exposed around birth to higher levels of measles (odds ratio for trend = 2.3, 95% confidence interval 1.3-4.2, p = 0.01). For other diagnostic groups, there was no consistent evidence of an association between risk and exposure to infections. Although the significant association observed for Hodgkin's disease may be a chance finding, consequent to multiple hypothesis testing or the ecologic nature of the study, it is consistent with other recent epidemiologic results suggesting that the risk of Hodgkin's disease may be associated with exposure to infections. © 2003 Wiley-Liss, Inc.

Publication metadata

Author(s): Nyari TA, Dickinson HO, Parker L

Publication type: Article

Publication status: Published

Journal: International Journal of Cancer

Year: 2003

Volume: 104

Issue: 6

Pages: 772-777

ISSN (print): 0020-7136

ISSN (electronic): 1097-0215

Publisher: Wiley-Blackwell


DOI: 10.1002/ijc.11030

PubMed id: 12640686


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