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Cytokine synergy, collagenases and cartilage collagen breakdown

Lookup NU author(s): Emeritus Professor Tim Cawston, Dr Jenny Milner, Dr Jonathan Catterall, Emeritus Professor Drew Rowan


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We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

Publication metadata

Author(s): Cawston TE, Milner JM, Catterall JB, Rowan AD

Publication type: Article

Publication status: Published

Journal: Biochemical Society Symposium

Year: 2003

Volume: 70

Pages: 125-133

ISSN (print): 0067-8694

ISSN (electronic): 1744-1439

Publisher: Portland Press


PubMed id: 14587288