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Lookup NU author(s): Emeritus Professor Tim Cawston,
Dr Jenny Milner,
Dr Jonathan Catterall,
Emeritus Professor Drew Rowan
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We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.
Author(s): Cawston TE, Milner JM, Catterall JB, Rowan AD
Publication type: Article
Publication status: Published
Journal: Biochemical Society Symposium
ISSN (print): 0067-8694
ISSN (electronic): 1744-1439
Publisher: Portland Press
PubMed id: 14587288