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Pyrocoll, an antibiotic, antiparasitic and antitumor compound produced by a novel alkaliphilic Streptomyces strain

Lookup NU author(s): Professor Michael Goodfellow


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A new secondary metabolite was detected in the culture extract of Streptomyces sp. AK 409 by HPLC-diode-array screening. The metabolite was identified as pyrocoll, which is known to be a constituent of cigarette smoke. Pyrocoll is known as a synthetic compound, but until now had not been isolated as a natural product from a microorganism. The compound showed biological activity against various Arthrobacter strains, filamentous fungi, several pathogenic protozoa, and some human tumor cell lines.

Publication metadata

Author(s): Dieter A, Hamm A, Fiedler H-P, Goodfellow M, Muller WEG, Brun R, Beil W, Bringmann G

Publication type: Article

Publication status: Published

Journal: Journal of Antibiotics

Year: 2003

Volume: 56

Issue: 7

Pages: 639-646

ISSN (print): 0021-8820

ISSN (electronic): 1881-1469

Publisher: Nature Publishing Group

PubMed id: 14513907