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Neurotransmitter abnormalities in vascular dementia

Lookup NU author(s): Dr Jennifer Court, Emeritus Professor Elaine Perry


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A number of neurotransmitters, including acetylcholine, serotonin, noradrenaline, and dopamine, modulate cerebral perfusion. In vascular dementia, reductions in markers of cholinergic innervation are consistently reported, and there are some indications that the serotonergic and dopaminergic systems may also be affected. Limited data indicate that the numbers of nucleus basalis, locus coeruleus, and dorsal raphé neurons and the density of neurotransmitter receptors are not reduced in the majority of cases. These data suggest neurotransmitter systems as a potential therapeutic target in vascular dementia.

Publication metadata

Author(s): Court JA, Perry EK

Publication type: Article

Publication status: Published

Journal: International Psychogeriatrics

Year: 2003

Volume: 15

Issue: 1

Pages: 81-87

Print publication date: 01/01/2003

ISSN (print): 1041-6102

ISSN (electronic): 1741-203X

Publisher: Cambridge University Press


DOI: 10.1017/S1041610203009013

PubMed id: 16191222


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