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Differential regulation of notch signal transduction in leukaemia and lymphoma cells in culture

Lookup NU author(s): Dr Gajanan Sherbet

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Abstract

The transduction of Notch signal plays an intricate role in cell differentiation and pathogenesis of haematological malignancies as well as in certain congenital conditions. We found no genomic changes in either gene in 34 leukaemic samples and 25 leukaemia and lymphoma cell lines. The functionality of Notch signalling was tested using HES1 gene activation. We show that Notch signalling is differentially regulated in T-acute lymphoblastic leukaemia (ALL) and B-lymphoma cells. The Notch pathway is intact in a majority of B-lymphoma cell lines, but EBNA2, which mimics notch function, can occasionally activate the pathway. In contrast, the Notch pathway is constitutively active in T-ALL. This is the first demonstration of a distinction between B-lymphomas and T-cell leukaemias in the functioning of the Notch-signalling pathway. This might be related to their pathogenesis. © 2003 Wiley-Liss, Inc.

Publication metadata

Author(s): Chiaramonte R, Calzavara E, Balordi F, Sabbadini M, Capello D, Gaidano G, Serra A, Comi P, Sherbet GV

Publication type: Article

Publication status: Published

Journal: Journal of Cellular Biochemistry

Year: 2003

Volume: 88

Issue: 3

Pages: 569-577

ISSN (print): 0730-2312

ISSN (electronic): 1097-4644

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/jcb.10383

DOI: 10.1002/jcb.10383

PubMed id: 12532332

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