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Lookup NU author(s): Professor Nicola CurtinORCiD,
Professor Herbie Newell,
Professor Alan Calvert,
Professor Roger Griffin,
Professor Bernard Golding
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Novel tricyclic benzimidazole carboxamide poly-(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been synthesized. Several compounds were found to be powerful chemopotentiators of temozolomide and topotecan in both A549 and LoVo cell lines. In vitro inhibition of PARP-1 was confirmed by direct measurement of NAD+ depletion and ADP-ribose polymer formation caused by chemically induced DNA damage.
Author(s): Skalitzky, D., Marakovits, J., Maegley, K., Ekker, A., Yu, X., Hostomsky, Z., Webber, S., Eastman, B., Almassy, R., Li, J., Curtin, N. J., Newell, D. R., Calvert, A. H., Griffin, R. J., Golding, B. T.
Publication type: Article
Publication status: Published
Journal: Journal of Medicinal Chemistry
Print publication date: 16/01/2003
ISSN (print): 00222623
PubMed id: 12519059
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