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Lookup NU author(s): Dr Gajanan Sherbet
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This review focuses on molocular events with the progression of gynaecological malignancies. The association of genetic abnormalities in cell cycle regulator genes, tumor suppressor genes and gene coding for growth factor receptors, with the progression of gynaecological cancers is reviewed. The possibility that some of these genes, cell cycle regulator genes in particular, could be co-operating with human papilloma virus genes in the induction and progression of gynaecological cancers is also discussed. The clinical effectiveness and reliability of these genes as markers of cancer progression and predictors of disease prognosis have been evaluated.
Author(s): Sherbet GV, Patil D
Publication type: Review
Publication status: Published
Journal: Anticancer Research
Year: 2003
Volume: 23
Issue: 2B
Pages: 1357-1371
ISSN (print): 0250-7005
ISSN (electronic): 1791-7530
PubMed id: 12820395