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Effects of different propofol infusion rates on EEG activity and AEP responses in rats

Lookup NU author(s): Luis Antunes, Dr Johnny RoughanORCiD, Emeritus Professor Paul FlecknellORCiD


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Parameters calculated from the auditory-evoked potential (AEP) recorded over the auditory cortex and from the electroencephalogram (EEG) recorded over the near vertex were compared in rats at three different infusion rates of propofol (62.5, 35 and 25 mg/kg/h). Depth of anaesthesia was assessed clinically using the strength of the pedal withdrawal reflex. Well-defined AEP responses were consistently obtained. As the propofol concentration was reduced, peak latencies decreased and peak to peak amplitudes increased. Amplitude and latency values were closely associated with the strength of the pedal withdrawal responses. Parameters calculated from the EEG showed no significant change as the propofol concentration was reduced. Periods of burst suppression became more frequent as the propofol infusion rate was increased. The study showed some of the difficulties that may be encountered when using EEG as a tool to assess depth of anaesthesia during propofol infusion. The AEP showed dose dependent changes in rats at different infusion rates of propofol. However, large variability between animals limits the use of this technique for monitoring depth of anaesthesia.

Publication metadata

Author(s): Antunes LM, Roughan JV, Flecknell PA

Publication type: Article

Publication status: Published

Journal: Journal of Veterinary Pharmacology and Therapeutics

Year: 2003

Volume: 26

Issue: 5

Pages: 369-376

Print publication date: 01/10/2003

ISSN (print): 0140-7783

ISSN (electronic): 1365-2885

Publisher: Wiley-Blackwell Publishing


DOI: 10.1046/j.1365-2885.2003.00499.x

PubMed id: 14633190


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