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Lookup NU author(s): Stefania Tabanella,
Professor Richard Jackson
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A range of substituted pyridyl amino acids have been prepared by palladium catalysed cross-coupling of serine-derived organozinc reagents with differently substituted halopyridines. Following this procedure a DMAP analogue has been synthesised and used as a building block in the preparation of two related tripeptides, which have been tested as catalysts in the kinetic resolution of trans-2-(N-acetylamino)cyclohexan-1-ol, resulting in modest enantioselectivity.
Author(s): Tabanella S, Valancogne I, Jackson RFW
Publication type: Article
Publication status: Published
Journal: Organic and Biomolecular Chemistry
ISSN (print): 1477-0520
ISSN (electronic): 1477-0539
Publisher: Royal Society of Chemistry
PubMed id: 14685328
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