Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Preparation of enantiomerically pure pyridyl amino acids from serine

Lookup NU author(s): Stefania Tabanella, Professor Richard Jackson

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

A range of substituted pyridyl amino acids have been prepared by palladium catalysed cross-coupling of serine-derived organozinc reagents with differently substituted halopyridines. Following this procedure a DMAP analogue has been synthesised and used as a building block in the preparation of two related tripeptides, which have been tested as catalysts in the kinetic resolution of trans-2-(N-acetylamino)cyclohexan-1-ol, resulting in modest enantioselectivity.

Publication metadata

Author(s): Tabanella S, Valancogne I, Jackson RFW

Publication type: Article

Publication status: Published

Journal: Organic and Biomolecular Chemistry

Year: 2003

Volume: 1

Issue: 23

Pages: 4254-4261

ISSN (print): 1477-0520

ISSN (electronic): 1477-0539

Publisher: Royal Society of Chemistry

URL: http://dx.doi.org/10.1039/b308750f

DOI: 10.1039/b308750f

PubMed id: 14685328

Altmetrics

Altmetrics provided by Altmetric

Share