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Lactonamycin Z, an antibiotic and antitumor compound produced by Streptomyces sanglieri strain AK 623

Lookup NU author(s): Professor Michael Goodfellow


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In summary, the structure elucidation revealed 1 to be closely related to lactonamycin, differing solely by the presence of an hydroxy group at C-3′ and the relative stereochemistry at C-4′ of the sugar moiety. Further differences are possible with respect to the absolute configuration, which has been determined for lactonamycin by X-ray crystallographic and optical rotation analysis). The antibacterial activities of 1 were determined by an agar plate diffusion assay. A weak activity against Gram-positive bacteria was detected as shown in Table 2. The antitumor activity of 1 was tested according to NCI guidelines) with human cell lines from gastric adenocarcinoma (HMO2), breast carcinoma (MCF 7), and hepatocellular carcinoma (Hep G2). 1 strongly inhibited the proliferation of HMO2 (IC50 value: 0.19 μg/m1), whereas the effects on MCF 7 and Hep G2 cell lines were less pronounced. The growth is inhibited in the G2/M cell cycle phase.

Publication metadata

Author(s): Holtzel A, Dieter A, Schmid DG, Brown R, Goodfellow M, Beil W, Jung G, Fiedler H-P

Publication type: Article

Publication status: Published

Journal: Journal of Antibiotics

Year: 2003

Volume: 56

Issue: 12

Pages: 1058-1061

Print publication date: 01/12/2003

ISSN (print): 0021-8820

ISSN (electronic): 1881-1469

Publisher: Nature Publishing Group

PubMed id: 15015734