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Butyrylcholinesterase and progression of cognitive deficits in dementia with Lewy bodies

Lookup NU author(s): Emeritus Professor Elaine Perry, Professor Ian McKeith, Dr Clive Ballard


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Butyrylcholinesterase is implicated in the pathology of AD. Selective inhibitors increase acetylcholine and improve cognitive function in animal models. In dementia with Lewy bodies, cholinergic activities are more affected than in AD. The authors report a highly significant association between temporal cortex butyrylcholinesterase activity and the rate of cognitive decline in a prospectively studied, autopsy-confirmed dementia with Lewy bodies series.

Publication metadata

Author(s): Perry E, McKeith I, Ballard C

Publication type: Article

Publication status: Published

Journal: Neurology

Year: 2003

Volume: 60

Issue: 11

Pages: 1852-1853

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X

Publisher: Lippincott Williams & Wilkins

PubMed id: 12796550