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Convergent effects of oxytocin and a δ-opioid agonist in the bed nuclei of the stria terminalis of the peripartum rat

Lookup NU author(s): Professor Colin Ingram

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Abstract

In the bed nuclei of the stria terminalis (BST), opioids may suppress the facilitatory effect of oxytocin on its own release pre-partum. In vitro electrophysiological recording showed that in virgin, late-pregnant, and lactating rats, a δ-opioid agonist inhibited a high proportion of BST neurons, many of which were also oxytocin responsive. Response magnitude did not differ significantly between groups, suggesting that the postulated pre-partum increase in opioid tone does not involve postsynaptic changes in neuronal sensitivity. © 2003 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Wilson BC, Ingram CD

Publication type: Article

Publication status: Published

Journal: Brain Research

Year: 2003

Volume: 991

Issue: 1-2

Pages: 267-270

ISSN (print): 0006-8993

ISSN (electronic): 1872-6240

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.brainres.2003.08.013

DOI: 10.1016/j.brainres.2003.08.013

PubMed id: 14575903

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