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Long-term immunologic effects of alemtuzumab: Immune reconstitution and immune function after alemtuzumab therapy for autoimmune disease

Lookup NU author(s): Professor John IsaacsORCiD

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Abstract

In summary, alemtuzumab resulted in profound and prolonged lymphopenia, particularly affecting CD4+ T cells in a variety of autoimmune conditions. Critically, long-term follow-up data of more than 200 patients showed that alemtuzumab therapy was not associated with an obvious increase in morbidity or mortality.

Publication metadata

Author(s): Isaacs JD

Publication type: Article

Publication status: Published

Journal: Transplantation Reviews

Year: 2003

Volume: 17

Issue: 4 (suppl. 1)

Pages: S12-S15

ISSN (print): 0955-470X

ISSN (electronic): 1557-9816

Publisher: WB Saunders Co.

URL: http://dx.doi.org/10.1016/j.trre.2003.07.006

DOI: 10.1016/j.trre.2003.07.006

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