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Sarcoglycans of the zebrafish: Orthology and localization to the sarcolemma and myosepta of muscle

Lookup NU author(s): Dr Louise VB Anderson

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Abstract

The zebrafish is an established model of vertebrate development and is also receiving increasing attention in terms of human disease modelling. In order to provide experimental support to realize this modelling potential, we report here the identification of apparent orthologues of many critical members of the dystrophin-associated glycoprotein complex (DGC) that have been implicated in a diverse range of neuromuscular disorders. In addition, immunohistochemical studies show the localization of the DGC to the sarcolemma of adult zebrafish muscle and in particular the myosepta. Together, these data suggest that the DGC in adult zebrafish may play a highly conserved functional role in muscle architecture that, when disrupted, could offer insight into human neuromuscular disease processes. © 2003 Elsevier Science (USA). All rights reserved.

Publication metadata

Author(s): Chambers SP, Anderson LVB, Maguire GM, Dodd A, Love DR

Publication type: Article

Publication status: Published

Journal: Biochemical and Biophysical Research Communications

Year: 2003

Volume: 303

Issue: 2

Pages: 488-495

ISSN (print): 0006-291X

ISSN (electronic): 1090-2104

Publisher: Academic Press

URL: http://dx.doi.org/10.1016/S0006-291X(03)00355-3

DOI: 10.1016/S0006-291X(03)00355-3

PubMed id: 12659844

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