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Replicative senescence and the art of counting

Lookup NU author(s): Professor Thomas von Zglinicki


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The idea that aging is largely the result of (endogeneous) stress appears to be at odds with the concept of biological 'clocks', which seem to programme and terminate cellular aging processes. Here, data are reviewed that show that telomeres, the major clock identified in human cells so far, do in fact measure stress and damage accumulation much more than simple mitotic time. Telomere shortening is significantly stress-dependent due to a telomere-specific damage repair deficiency. This identifies telomere-driven human cell replicative senescence as a stress response with high potential importance for human aging. © 2003 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Von Zglinicki T

Publication type: Review

Publication status: Published

Journal: Experimental Gerontology

Year: 2003

Volume: 38

Issue: 11-12

Pages: 1259-1264

Print publication date: 01/11/2003

ISSN (print): 0531-5565

ISSN (electronic): 1873-6815


DOI: 10.1016/j.exger.2003.09.015

PubMed id: 14698805