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Regional cerebral blood flow in Parkinson's disease with and without dementia

Lookup NU author(s): Dr Michael FirbankORCiD, Dr Sean Colloby, Professor David Burn, Professor Ian McKeith, Professor John O'Brien


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Tc99 HMPAO SPECT and T1 weighted 3D MRI scans were acquired in cognitively intact subjects with Parkinson's disease (PD) (n = 31), and in PD subjects with dementia (PDD) (n = 34), healthy controls (n = 37), those with Alzheimer's disease (AD) (n = 32), and those with dementia with Lewy bodies (DLB) (n = 15). We used SPM99 to look for regions which showed a reduction in perfusion on SPECT not related to associated structural brain changes assessed by a MRI scan. The precuneus and inferior lateral parietal regions showed a perfusion deficit in Parkinson's disease with dementia, similar to the pattern observed in DLB. In comparison, AD showed a perfusion deficit in the midline parietal region, in a more anterior and inferior location than in PDD, involving the posterior cingulate as well as the precuneus. The perfusion deficits in PDD are similar those in DLB, and in a location associated with visual processing, and may be associated with the visuospatial perception deficits which are present in persons with DLB and PDD. © 2003 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Firbank MJ, Colloby SJ, Burn DJ, McKeith IG, O'Brien JT

Publication type: Article

Publication status: Published

Journal: NeuroImage

Year: 2003

Volume: 20

Issue: 2

Pages: 1309-1319

ISSN (print): 1053-8119

ISSN (electronic): 1095-9572

Publisher: Academic Press


DOI: 10.1016/S1053-8119(03)00364-1

PubMed id: 14568499


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