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Lookup NU author(s): Professor Mushtaq Saleem, Dr Richard WilkinsORCiD, Dr David Mantle
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To determine the possible involvement of the process of intracellular protein catabolism in the development of insecticide resistance, we have compared the activities of a comprehensive range of cytoplasmic and lysosomal proteolytic enzymes in 48 hours starved and un-starved resistant and susceptible strains of Musca domestica. Compared to un-starved, the homogenates of 48 hours starved house flies of both resistant and susceptible strains showed elevated levels of most of the poteases tested in this study. Thus in susceptible strain, leucyl aminopeptidase, proline endopeptidase and cathepsin L showed elevated levels in starved than un-starved by 42%, 28% and 23%, respectively, while the remaining proteases exhibited minor fluctuations. On the other hand, in resistant strain, leucyl aminopeptidase (58%), proline endopeptidase (41%) and cathepsin L (38%) showed elevated levels whereas the remaining proteases exhibited minor deviations. The results suggested that higher induction of proteases in starved resistant than susceptible strain may be important in the development of insecticide resistance in M. domestica.
Author(s): Saleem MA, Wilkins RM, Mantle D, Ahmad S, Shakoori AR
Publication type: Article
Publication status: Published
Journal: Pakistan Journal of Zoology
Year: 2003
Volume: 35
Issue: 4
Pages: 311-318
Print publication date: 01/01/2003
ISSN (print): 0030-9923
ISSN (electronic):
Publisher: Zoological Society of Pakistan
