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Lookup NU author(s): Professor Bernard Connolly,
Dr Brian Wilson
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Archaeal family-B DNA polymerases possess a novel uracil-sensing mechanism. A specialized pocket scans the template, ahead of the replication fork, for the presence of uracil; on encountering this base, DNA synthesis is stalled. The structural basis for uracil recognition by polymerases is described and compared with other uracil-recognizing enzymes (uridine-triphosphate pyrophophatases and uracil-DNA glycosylases). Remarkably, protein-protein interactions between all three archaeal uracil sensors are observed; possibly the enzymes co-operate to efficiently eliminate uracil from archaeal genomes.
Author(s): Connolly BA, Fogg MJ, Shuttleworth G, Wilson BT
Publication type: Article
Publication status: Published
Journal: Biochemical Society Transactions
ISSN (print): 0300-5127
ISSN (electronic): 1470-8752
Publisher: Portland Press Ltd.
PubMed id: 12773186
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