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Evaluating the role of solvent and borane on the enantioselectivity of the oxazaborolidine reduction of prochiral ketones using catalysts derived from cis-(1R,2S)-1-amino-indan-2-ol

Lookup NU author(s): Dr Simon Jones

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Abstract

The dependency of the enantioselectivity on the solvent and hydride source for the asymmetric reduction of acetophenone catalysed by the oxazaborolidine derived from cis-(1R,2S)-1-amino-indan-2-ol have been investigated. 11B NMR studies have implied that monomer/dimer ratios are important for achieving high enantioselectivities. © 2003 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Gilmore NJ, Jones S

Publication type: Article

Publication status: Published

Journal: Tetrahedron: Asymmetry

Year: 2003

Volume: 14

Issue: 15

Pages: 2115-2118

ISSN (print): 0957-4166

ISSN (electronic): 1362-511X

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/S0957-4166(03)00401-4

DOI: 10.1016/S0957-4166(03)00401-4

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