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A lifecourse study of risk for hyperinsulinaemia, dyslipidaemia and obesity (the central metabolic syndrome) at age 49-51 years

Lookup NU author(s): Professor Louise Parker, Dr Douglas Lamont, Professor Nigel Unwin, Professor Mark PearceORCiD, Dr Stuart Bennett, Dr Heather Dickinson, Professor Martin White, Professor John Mathers, Emeritus Professor Sir George Sir George Alberti, Emeritus Professor Alan Craft


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Aims: Suboptimal maternal nutrition and catch-up growth in early childhood predispose to insulin resistance and other components of metabolic syndrome in later life. A central metabolic syndrome (CMS) has been identified comprising obesity, dyslipidaemia and insulin resistance. This study was designed to investigate determinants of risk for CMS. Methods: Persons born in Newcastle in May and June 1947 (n = 358) were followed to 1996-1998. A lifecourse approach was used to estimate the proportion of variance in a summary measure of CMS at age 49-51 years accounted for by factors operating at different stages of life. Results: After adjustment for other early life variables, childhood catch-up growth in men accounted for significant variation in the CMS score independent of adult lifestyle. In adulthood, exercise level in men and smoking in both genders were independently associated with CMS. Over two-thirds of explained variation in the CMS score in women, and almost half in men, was accounted for exclusively by factors measured in adulthood. Conclusions: While risk for CMS in men is compounded by early life disadvantage, promotion of a healthier adult lifestyle and a reduction in the number of people taking up smoking would appear to be the public health interventions most likely to reduce the prevalence of CMS in middle age.

Publication metadata

Author(s): Bennett SMA; Parker L; Unwin N; White MJR; Craft AW; Dickinson HO; Lamont DW; Pearce MS; Mathers JC; Alberti KGMM

Publication type: Article

Publication status: Published

Journal: Diabetic Medicine

Year: 2003

Volume: 20

Issue: 5

Pages: 406-415

ISSN (print): 0742-3071

ISSN (electronic): 1464-5491

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1046/j.1464-5491.2003.00949.x

PubMed id: 12752491


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