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Depression with late onset is associated with right frontal lobe atrophy

Lookup NU author(s): Dr Emma Burton, Emeritus Professor Nicol Ferrier, Professor Ian McKeith, Professor John O'Brien


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Background. The objective of this study was to determine whether older adults with first-ever onset of depression after age 60 years (late onset depression, LOD) have smaller frontal lobes than elderly patients with early-onset depression (EOD) and aged controls. Method. Twenty-seven subjects with LOD, 24 with EOD and 37 controls underwent volumetric MRI to determine right and left frontal lobe volumes and total brain volume. Results. The right frontal volume of subjects with LOD was 8.0% and 5.6 % smaller than that of patients with EOD (P < 0.01) and controls (NS) respectively. Volume of the left frontal lobe was not significantly different from EOD or controls. All analyses were adjusted for age, gender and total brain volume. Unlike controls and those with EOD, patients with LOD did not display a significant positive correlation between cognitive scores and total brain, left frontal or right frontal volumes. Conclusion. LOD is associated with right frontal lobe atrophy and loss of the correlation between cognitive performance and brain volume. This adds support to the fronto-striatal hypothesis of depression and suggests that structural brain changes have a particular role in cases of LOD.

Publication metadata

Author(s): Almeida OP, Burton EJ, Ferrier N, McKeith IG, O'Brien JT

Publication type: Article

Publication status: Published

Journal: Psychological Medicine

Year: 2003

Volume: 33

Issue: 4

Pages: 675-681

Print publication date: 01/05/2003

ISSN (print): 0033-2917

ISSN (electronic): 1469-8978

Publisher: Cambridge University Press


DOI: 10.1017/S003329170300758X

PubMed id: 12785469


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