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Prostaglandin production by melanocytic cells and the effect of α-melanocyte stimulating hormone

Lookup NU author(s): Professor Anthony Thody


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Prostaglandins are potent mediators of the inflammatory response and are also involved in cancer development. In this study, we show that human melanocytes and FM55 melanoma cells express cyclooxygenase-1 and -2 (COX-1 and -2) and thus have the capability to produce prostaglandins. The FM55 cells produced predominantly PGE2 and PGF2α, whereas the HaCaT keratinocyte cell line produced mainly PGE2. The anti-inflammatory peptide, α-melanocyte stimulating hormone (α-MSH), reduced prostaglandin production in FM55 and HaCaT cells and reversed the effect of the pro-inflammatory cytokine TNF-α in the former. These results indicate that melanocytes produce prostaglandins and that α-MSH, by inhibiting this response, may play an important role in regulating inflammatory responses in the skin. © 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

Publication metadata

Author(s): Nicolaou A, Estdale SE, Tsatmali M, Herrero DP, Thody AJ

Publication type: Article

Publication status: Published

Journal: FEBS Letters

Year: 2004

Volume: 570

Issue: 1-3

Pages: 223-226

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: Elsevier BV


DOI: 10.1016/j.febslet.2004.06.041

PubMed id: 15251468


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