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Functional genomics and proteomics: Application in neurosciences

Lookup NU author(s): Kate Wilson, Dr Christopher Morris

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Abstract

The sequencing of the complete genome for many organisms, including man, has opened the door to the systematic understanding of how complex structures such as the brain integrate and function, not only in health but also in disease. This blueprint, however, means that the piecemeal analysis regimes of the past are being rapidly superseded by new methods that analyse not just tens of genes or proteins at any one time, but thousands, if not the entire repertoire of a cell population or tissue under investigation. Using the most appropriate method of analysis to maximise the available data therefore becomes vital if a complete picture is to be obtained of how a system or individual cell is affected by a treatment or disease. This review examines what methods are currently available for the large scale analysis of gene and protein expression, and what are their limitations.

Publication metadata

Author(s): Wilson KE, Ryan MM, Prime JE, Pashby DP, Orange PR, O'Beirne G, Whateley JG, Bahn S, Morris CM

Publication type: Review

Publication status: Published

Journal: Journal of Neurology, Neurosurgery and Psychiatry

Year: 2004

Volume: 75

Issue: 4

Pages: 529-538

ISSN (print): 0022-3050

ISSN (electronic): 1468-330X

URL: http://dx.doi.org/10.1136/jnnp.2003.026260

DOI: 10.1136/jnnp.2003.026260

PubMed id: 15026490

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