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Stereochemistry of hydrogen removal from the 'unactivated' C-3 position of 4-hydroxybutyryl-CoA catalysed by 4-hydroxybutyryl-CoA dehydratase

Lookup NU author(s): Emeritus Professor Bernard Golding

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Abstract

(R)- and (S)-γ-[3-2H1]butyrolactones have been synthesised from (R)- and (S)-glycidol, respectively, and used to demonstrate that it is the pro-(S) hydrogen atom that is stereospecifically abstracted from C-3 of 4-hydroxybutyryl-CoA by 4-hydroxybutyryl-CoA dehydratase, and that this atom is not returned to C-4.

Publication metadata

Author(s): Scott R, Naser U, Friedrich P, Selmer T, Buckel W, Golding BT

Publication type: Article

Publication status: Published

Journal: Chemical Communications

Year: 2004

Volume: 10

Issue: 10

Pages: 1210-1211

Date deposited: 09/07/2010

ISSN (print): 1359-7345

ISSN (electronic): 1364-548X

Publisher: Royal Society of Chemistry

URL: http://dx.doi.org/10.1039/b402322f

DOI: 10.1039/b402322f

PubMed id: 15136842

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