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L-arginine-induced experimental pancreatitis

Lookup NU author(s): Dr Zoltan Rakonczay


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Despite medical treatment, the lethality of severe acute pancreatitis is still high (20-30%). Therefore, it is very important to find good animal models to characterise the events of this severe disease. In 1984, Mizunuma et al. developed a new type of experimental necrotizing pancreatitis by intraperitoneal administration of a high dose of L-arginine in rats. This non-invasive model is highly reproducible and produces selective, dose-dependent acinar cell necrosis. Not only is this a good model to study the pathomechanisms of acute necrotizing pancreatitis, but it is also excellent to observe and influence the time course changes of the disease. By writing this review we iluminate some new aspects of cell physiology and pathology of acute necrotizing pancreatitis. Unfortunately, the reviews about acute experimental pancreatitis usually did not discuss this model. Therefore, the aim of this manuscript was to summarise the observations and address some challenges for the future in L-arginine-induced pancreatitis. Copyright © 2004 by The WJG Press.

Publication metadata

Author(s): Heygi P, Rakonczay Jr Z, Sari R, Gog C, Lonovics J, Takacs T, Czako L

Publication type: Review

Publication status: Published

Journal: World Journal of Gastroenterology

Year: 2004

Volume: 10

Issue: 14

Pages: 2003-2009

ISSN (print): 1007-9327

ISSN (electronic): 1009-3079


PubMed id: 15237423