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High-mobility group protein 1(Y): Metastasis-associated or metastasis-inducing?

Lookup NU author(s): Alice Evans, Professor Thomas Lennard, Dr Barry Davies


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Metastasis is the major cause of mortality and morbidity for patients with cancer. The high-mobility group protein 1(Y) [HMG-1(Y)] has a role in the transcription of many genes involved at different steps in the metastatic cascade and has been linked with cancer in human and animal models. This may represent a potential therapeutic target for patients. The following review summarizes and critically appraises the evidence for the role of HMG-1(Y) in metastasis. © 2004 Wiley-Liss, Inc.

Publication metadata

Author(s): Evans, A., Lennard, T.W.J., Davies, B.R.

Publication type: Review

Publication status: Published

Journal: Journal of Surgical Oncology

Year: 2004

Volume: 88

Issue: 2

Pages: 86-99

Print publication date: 01/11/2004

ISSN (print): 0022-4790

ISSN (electronic): 1096-9098


DOI: 10.1002/jso.20136

PubMed id: 15499602