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Lookup NU author(s): Professor Kim Bartlett,
Dr Simon Eaton
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Mitochondrial β-oxidation is a complex pathway involving, in the case of saturated straight chain fatty acids of even carbon number, at least 16 proteins which are organized into two functional subdomains; one associated with the inner face of the inner mitochondrial membrane and the other in the matrix. Overall, the pathway is subject to intramitochondrial control at multiple sites. However, at least in the liver, carnitine palmitoyl transferase I exerts approximately 80% of control over pathway flux under normal conditions. Clearly, when one or more enzyme activities are attenuated because of a mutation, the major site of flux control will change.
Author(s): Bartlett K, Eaton S
Publication type: Note
Publication status: Published
Journal: European Journal of Biochemistry
ISSN (print): 0014-2956
PubMed id: 14728673