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Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032

Lookup NU author(s): Professor Alan Bull, Dr Luis Maldonado, Emeritus Professor Alan Ward, Professor Michael Goodfellow

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Abstract

A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusion assay modified as an antagonism test. By this screening method, a family of three novel polycyclic polyketides named as abyssomicins was isolated from a marine strain of Verrucosispora. The main component abyssomicin C inhibits the pathway between chorismate and para-aminobenzoic acid and is strongly active against Gram-positive bacteria, including multi-resistant clinical isolates of Staphylococcus aureus.

Publication metadata

Author(s): Riedlinger J, Reicke A, Zahner H, Krismer B, Bull AT, Maldonado LA, Ward AC, Goodfellow M, Bister B, Bischoff D, Sussmuth RD, Fiedler H-P

Publication type: Article

Publication status: Published

Journal: Journal of Antibiotics

Year: 2004

Volume: 57

Issue: 4

Pages: 271-279

Print publication date: 01/04/2004

ISSN (print): 0021-8820

ISSN (electronic): 1881-1469

Publisher: Nature Publishing Group

PubMed id: 15217192

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