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Lookup NU author(s): Professor Alan Bull,
Dr Luis Maldonado,
Emeritus Professor Alan Ward,
Professor Michael Goodfellow
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A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusion assay modified as an antagonism test. By this screening method, a family of three novel polycyclic polyketides named as abyssomicins was isolated from a marine strain of Verrucosispora. The main component abyssomicin C inhibits the pathway between chorismate and para-aminobenzoic acid and is strongly active against Gram-positive bacteria, including multi-resistant clinical isolates of Staphylococcus aureus.
Author(s): Riedlinger J, Reicke A, Zahner H, Krismer B, Bull AT, Maldonado LA, Ward AC, Goodfellow M, Bister B, Bischoff D, Sussmuth RD, Fiedler H-P
Publication type: Article
Publication status: Published
Journal: Journal of Antibiotics
Print publication date: 01/04/2004
ISSN (print): 0021-8820
ISSN (electronic): 1881-1469
Publisher: Nature Publishing Group
PubMed id: 15217192