Toggle Main Menu Toggle Search

Open Access padlockePrints

Salivary proteins and cytokines in drug-induced gingival overgrowth

Lookup NU author(s): Emeritus Professor Robin Seymour, Professor Mark Thomason


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Little is known about the involvement of saliva in gingival overgrowth (GO). It was hypothesized that, in this situation, the composition of saliva is altered. Thus, proteins, albumin, cytokines, and growth factors in whole and glandular saliva were investigated. Differences between glandular and gingival contributions to the composition of saliva were explored in patients medicated with cyclosporin who exhibited GO (responders), those without GO (non-responders), and non-medicated subjects (controls). In whole saliva, interleukin-1α (IL-1α), IL-6, IL-8, epidermal growth factor (EGF), nerve growth factor (NGF), and albumin were detected, but in glandular saliva only EGF and NGF were identified. Albumin and IL-6 differed significantly between responders and controls, although the overall profile of salivary proteins remained unchanged. Thus, inflammatory cytokines and albumin are confined to whole saliva and are associated with GO, whereas its content of EGF and NGF appears unaffected by cyclosporin.

Publication metadata

Author(s): Ruhl S, Hamberger S, Betz R, Sukkar T, Schmalz G, Seymour RA, Hiller K-A, Thomason JM

Publication type: Article

Publication status: Published

Journal: Journal of Dental Research

Year: 2004

Volume: 83

Issue: 4

Pages: 322-326

ISSN (print): 0022-0345

ISSN (electronic): 1544-0591

Publisher: Sage


DOI: 10.1177/154405910408300410

PubMed id: 15044507


Altmetrics provided by Altmetric