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Fasting homocysteine levels in adults with type 1 diabetes and retinopathy

Lookup NU author(s): Dr Bakri Saeed, Dr Andrew Skillen, Dr Jolanta Weaver


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Background and methods: Whether hyperhomocysteinemia is associated with diabetic retinopathy is still being debated. We measured homocysteine and thrombomodulin, a marker of endothelial cell damage, in patients with type 1 diabetes mellitus and retinopathy (n=25) and in a well-matched group of diabetic patients without retinopathy (n=23). All patients had normal serum creatinine and no macroalbuminuria. Results: Fasting homocysteine levels were higher in the group with retinopathy than in the group without retinopathy (8.75±1.9 vs. 7.69±1.6 μmol/l, P<0.05). Microalbuminuria was more prevalent in the group with diabetic retinopathy and it correlated with homocysteine levels in this group (p<0.05). Microalbuminuria was the most powerful independent determinant of homocysteine levels in multiple regression analysis in the group with retinopathy (p<0.01). Thrombomodulin levels were not different in the two groups (36.6±9.7 vs. 34.9±11.1, p>0.1) and there was no correlation between homocysteine and thrombomodulin levels in either group. Conclusions: The slight rise in homocysteine levels in patients with diabetic retinopathy was possibly caused by the early nephropathy as indicted by microalbuminuria. This small rise in homocysteine levels was not associated with endothelial dysfunction, as measured by serum thrombomodulin levels. © 2004 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Saeed BO, Nixon SJ, White AJ, Summerfield GP, Skillen AW, Weaver JU

Publication type: Article

Publication status: Published

Journal: Clinica Chimica Acta

Year: 2004

Volume: 341

Issue: 1-2

Pages: 27-32

ISSN (print): 0009-8981

ISSN (electronic): 1873-3492

Publisher: Elsevier BV


DOI: 10.1016/j.cccn.2003.10.034

PubMed id: 14967155


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