Toggle Main Menu Toggle Search

Open Access padlockePrints

Warfarin and celecoxib interaction in the setting of cytochrome P450 (CYP2C9) polymorphism with bleeding complication

Lookup NU author(s): Professor Ann DalyORCiD, Dr Santosh Gupta


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Drug metabolism may be perturbed by genetically determined differences in the metabolic activity of cytochrome P450 enzymes. The authors encountered extensive bleeding in a patient receiving warfarin for anticoagulation after the introduction of celecoxib, an anti-inflammatory drug. As the CYP2C9 enzyme metabolises these drugs, it was determined whether variant alleles were responsible for altering warfarin handling. Genetic analysis established that the patient was a compound heterozygote with CYP2C9*2 and *3 variant alleles, which exhibit lower drug metabolising capacity and enhance susceptibility to drug toxicity.

Publication metadata

Author(s): Malhi H, Atac B, Daly AK, Gupta S

Publication type: Article

Publication status: Published

Journal: Postgraduate Medical Journal

Year: 2004

Volume: 80

Issue: 940

Pages: 107-109

Print publication date: 01/02/2004

ISSN (print): 0032-5473

ISSN (electronic): 1469-0756

Publisher: BMJ Group


DOI: 10.1136/pmj.2003.006478

PubMed id: 14970301


Altmetrics provided by Altmetric