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Prevalence of gingival overgrowth in transplant patients immunosuppressed with tacrolimus

Lookup NU author(s): Professor Janice EllisORCiD, Emeritus Professor Robin Seymour, Dr John TaylorORCiD, Professor Mark Thomason


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Aims: The study aims to determine the prevalence and severity of gingival overgrowth in a group of adult organ transplant recipients immunosuppressed with tacrolimus in comparison with ciclosporin, and to examine various risk factors for the development of gingival overgrowth. Methods: Forty patients taking tacrolimus were compared with 197 ciclosporin patients. Demographic, pharmacological and periodontal data were recorded for all patients. Comparison between the groups was made using independent sample t-tests, χ2 statistic or Mann-Whitney test. The effects of risk variables on overgrowth severity were examined using forward and backward stepwise regression analysis. Results: Those taking tacrolimus had a significantly lower mean gingival overgrowth score (14.1%) compared with ciclosporin (22.4%). Fifteen percent of the tacrolimus group had clinically significant gingival overgrowth compared with 30% in the ciclosporin group (p = 0.053). Conclusions: The prevalence and severity of gingival overgrowth is less in adult transplant patients taking tacrolimus compared with ciclosporin. Concomitant use of calcium channel blockers and previous medication with ciclosporin are significant risk factors for the presence and severity of gingival overgrowth. Patients who have alteration of their immunosuppressant from ciclosporin to tacrolimus may persist in demonstrating gingival overgrowth attributable to their ongoing therapy with calcium channel blockers. © Blackwell Munksgaard, 2004.

Publication metadata

Author(s): Ellis JS, Seymour RA, Taylor JJ, Thomason JM

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Periodontology

Year: 2004

Volume: 31

Issue: 2

Pages: 126-131

ISSN (print): 0303-6979

ISSN (electronic): 1600-051X

Publisher: Wiley-Blackwell


DOI: 10.1111/j.0303-6979.2004.00459.x

PubMed id: 15016038


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