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In vitro anti-β-secretase and dual anti-cholinesterase activities of Camellia sinensis L. (tea) relevant to treatment of dementia

Lookup NU author(s): Dr Edward Okello, Dr Sergey Savelev, Emeritus Professor Elaine Perry

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Abstract

The primary target of licensed drugs for the treatment of Alzheimer's disease is the inhibition of the enzyme acetylcholinesterase, although preventing β-amyloidosis is a prime target for drugs in development. The in vitro dual anti-cholinesterase and β-secretase activities of Camellia sinensis L. extract (tea) is reported. Green and black tea inhibited human acetylcholinesterase (AChE) with IC50 values of 0.03 mg/mL and 0.06 mg/mL respectively, and human butyrylcholinesterase (BuChE) with IC50 values 0.05 mg/mL. Green tea at a final assay concentration of 0.03 mg/mL inhibited β-seretase by 38%. These novel findings suggest that tea infusions contain biologically active principles, perhaps acting synergisticaly, that may be used to retard the progression of the disease assuming that these principles, yet to be identified, reach the brain. Copyright © 2004 John Wiley & Sons, Ltd.


Publication metadata

Author(s): Okello EJ, Savelev SU, Perry EK

Publication type: Article

Publication status: Published

Journal: Phytotherapy Research

Year: 2004

Volume: 18

Issue: 8

Pages: 624-627

Print publication date: 01/08/2004

ISSN (print): 0951-418X

ISSN (electronic): 1099-1573

Publisher: John Wiley & Sons Ltd

URL: http://dx.doi.org/10.1002/ptr.1519

DOI: 10.1002/ptr.1519

PubMed id: 15476306


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