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Lookup NU author(s): Dr Ed Okello,
Dr Sergey Savelev,
Emeritus Professor Elaine Perry
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The primary target of licensed drugs for the treatment of Alzheimer's disease is the inhibition of the enzyme acetylcholinesterase, although preventing β-amyloidosis is a prime target for drugs in development. The in vitro dual anti-cholinesterase and β-secretase activities of Camellia sinensis L. extract (tea) is reported. Green and black tea inhibited human acetylcholinesterase (AChE) with IC50 values of 0.03 mg/mL and 0.06 mg/mL respectively, and human butyrylcholinesterase (BuChE) with IC50 values 0.05 mg/mL. Green tea at a final assay concentration of 0.03 mg/mL inhibited β-seretase by 38%. These novel findings suggest that tea infusions contain biologically active principles, perhaps acting synergisticaly, that may be used to retard the progression of the disease assuming that these principles, yet to be identified, reach the brain. Copyright © 2004 John Wiley & Sons, Ltd.
Author(s): Okello EJ, Savelev SU, Perry EK
Publication type: Article
Publication status: Published
Journal: Phytotherapy Research
Print publication date: 01/08/2004
ISSN (print): 0951-418X
ISSN (electronic): 1099-1573
Publisher: John Wiley & Sons Ltd
PubMed id: 15476306
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