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Pantoprazole-induced acute interstitial nephritis

Lookup NU author(s): Dr Iain Moore, Professor John SayerORCiD, Dr Saeed Ahmed, Dr John Tapson


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Pantoprazole is a proton-pump inhibitor (PPI) that is commonly prescribed for the treatment of gastroesophageal reflux-related disorders. There are many documented side effects of PPIs. Here we report a case of acute interstitial nephritis, which developed after 6 weeks of treatment with pantoprazole. A 23-year-old man presented with acute renal failure requiring renal replacement therapy. Acute interstitial nephritis was diagnosed by renal biopsy and was successfully treated with corticosteroids and withdrawal of pantoprazole. Drug-induced acute interstitial nephritis can occur with PPIs such as pantoprazole and vigilance needs to be maintained.

Publication metadata

Author(s): Moore I, Sayer JA, Nayar A, Ahmed S, Tapson JS

Publication type: Article

Publication status: Published

Journal: Journal of Nephrology

Year: 2004

Volume: 17

Issue: 4

Pages: 580-581

Print publication date: 01/07/2004

ISSN (print): 1121-8428

ISSN (electronic): 1724-6059

Publisher: Wichtig Editore Srl

PubMed id: 15372423