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Regulation of cell cycle-specific gene expression through cyclin-dependent kinase-mediated phosphorylation of the forkhead transcription factor Fkh2p

Lookup NU author(s): Dr Aline Pic-Taylor, Professor Brian Morgan

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Abstract

The forkhead transcription factor Fkh2p acts in a DNA-bound complex with Mcm1p and the coactivator Ndd1p to regulate cell cycle-dependent expression of the CLB2 gene cluster in Saccharomyces cerevisiae. Here, we demonstrate that Fkh2p is a target of cyclin-dependent protein kinases and that phosphorylation of Fkh2p promotes interactions between Fkh2p and the coactivator Ndd1p. These phosphorylation-dependent changes in the Fkh2p-Ndd1p complex play an important role in the cell cycle-regulated expression of the CLB2 cluster. Our data therefore identify an important regulatory target for cyclin-dcpendent kinases in the cell cycle and further our molecular understanding of the key cell cycle regulatory transcription factor Fkh2p.

Publication metadata

Author(s): Pic-Taylor A, Darieva Z, Morgan BA, Sharrocks AD

Publication type: Article

Publication status: Published

Journal: Molecular and Cellular Biology

Year: 2004

Volume: 24

Issue: 22

Pages: 10036-10046

ISSN (print): 0270-7306

ISSN (electronic): 1098-5549

Publisher: American Society for Microbiology

URL: http://dx.doi.org/10.1128/MCB.24.22.10036-10046.2004

DOI: 10.1128/MCB.24.22.10036-10046.2004

PubMed id: 15509804

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