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Turning it on and off: M-phase promoting factor during meiotic maturation and fertilization

Lookup NU author(s): Professor Keith Jones


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Maturation (M-phase) promoting factor (MPF) plays a pivotal role in oocytes during their maturation. This review concentrates on its function at three important time-points. First, its activation during meiotic progression from prophase I arrest at germinal vesicle breakdown. Second, its role during the transition from meiosis I to meiosis II, a defining feature of meiosis involving segregation of homologous chromosomes. Third, maintenance of its activity at metaphase II arrest and the necessity for its destruction during oocyte activation. An understanding of how oocytes switch it on and turn it off underpins much of the basic cell biology of oocyte maturation.

Publication metadata

Author(s): Jones KT

Publication type: Review

Publication status: Published

Journal: Molecular Human Reproduction

Year: 2004

Volume: 10

Issue: 1

Pages: 1-5

ISSN (print): 1360-9947

ISSN (electronic): 1460-2407


DOI: 10.1093/molehr/gah009