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Lookup NU author(s): Professor Philip Bradley,
Dr Alison Webb
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Post-synaptic GABAB responses (slow, late hyperpolarisations which can be eliminated by perfusion with phaclofen) can be recorded in vitro from many, but not all, neurones in the intermediate medial hyperstriatum ventrale (IMHV). The IMHV is an area of the chick forebrain which is remarkable for its plasticity, and for its essential role in two specific types of early learning - imprinting, and a form of one-trial passive-avoidance learning. Post-synaptic GABAB responses are strongly statistically associated with other properties (such as high membrane resistance) which are, themselves, dependent on a bird's past history. There is also evidence that their incidence changes with prior training in vivo and with age. GABAB hyperpolarisations are always offset to a varying extent by excitatory NMDA components. These two components follow a very similar time-course, so that the duration and (to a lesser extent), the magnitude of a response is controlled by the balance between the two systems. The evidence suggests that this balance fluctuates, and that its fluctuations determine the extent to which any neurone can function as a coincidence detector. © 2004 Elsevier B.V. All rights reserved.
Author(s): Bradley PM, Burns BD, Gowland CJ, Webb AC
Publication type: Article
Publication status: Published
Journal: Behavioural Brain Research
Print publication date: 05/11/2004
ISSN (print): 0166-4328
ISSN (electronic): 1872-7549
Publisher: Elsevier BV
PubMed id: 15325776
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